During our exclusive chat with Vincenzo Natali about Splice, his sci-fi thriller debuting at the Sundance Film Festival this weekend, he revealed that there is a chance we might one day see a sequel. In the film Clive (Adrien Brody) and Elsa (Sarah Polley) are young, brilliant and ambitious. The new animal species they engineered have made them rebel superstars of the scientific world. In secret, they introduce human DNA into the experiment. The result is something that is greater than the sum of its parts: a female animal-human hybrid that may be a step up on the evolutionary ladder. They think they may have created the perfect organism, until she makes a final shocking metamorphosis that could destroy them … and the rest of humanity.
“You know it’s funny, because without giving anything away, the film ends as though we’re trying to set up a sequel,” Natali told BD in an exclusive interview adding that it wasn’t his intention. “And I want to make it very clear that that was not my intention whatsoever. It just happens that I believed it was the best way to end the story. Like all my films actually are somewhat open-ended, so I think they invite that question. I really just want this movie to be released. (Laughs)”

He continues, “Here’s what I will say: after CUBE, which did have two sequels, of which I had no involvement whatsoever, I would not allow a second film to be made without my involvement. Simply because I want to protect that merchandise, as it were. I just felt that with CUBE, for better or worse, I wasn’t a part of that, and I wouldn’t have made some of the decisions that I think were made with the sequels. I would have done them a little differently. That’s not to say that they weren’t worthy sequels, but it’s just not the way I would have gone personally. So I think the same would be true with SPLICE, if that were in fact to happen.”