Shooting began this week on Academy Award winner Stefan Ruzowitzky’s action-thriller Patient Zero.

The feature stars Matt Smith (“Doctor Who,” Terminator Genisys), Natalie Dormer (“Game of Thrones”), John Bradley (“Game of Thrones”), Agyness Deyn (Clash of the Titans), and Academy Award nominee Stanley Tucci (The Hunger Games).

Production is based in the UK at Shepperton Studios and will shoot in and around London until April 18, 2015.

In Patient Zero, an unprecedented global pandemic of a super strain of rabies has turned the majority of humankind into highly intelligent, streamlined killers known as ‘The Infected.’ One victim, Morgan (Matt Smith), who is asymptomatic and can communicate with the infected, leads the last survivors on a hunt for Patient Zero and a cure.

Patient Zero is directed by Austrian writer/director Stefan Ruzowitzky, best known for the 2008 Academy Award® Winner for Best Foreign Film The Counterfeiters, and is from a screenplay written by Mike Le. Vincent Newman (We’re the Millers) produces along with executive producer Steve Norris (The Riot Club).

Cinematography is by Benedict Neuenfels (The Counterfeiters), production design by Jonathan Lee (Stealth), make-up and hair design by Jane Walker (The World’s End), costume design by Suzie Harman (RocknRolla), and VFX produced by Raoul Yorke-Bologinini (Sinister 2).