Tyrant (On the Plane) – Resident Evil CODE: Veronica
Apparently all you had to do to easily defeat this boss was stock up on explosive arrows beforehand. I wish I had known that back when I played it, because this guy took me several tries to beat, and based on the comments, other have had similar issues. Resident Evil CODE: Veronica is famous for being one of the most difficult games in the franchise, and no moment is more difficult than the Tyrant on the plane (for me, at least). Major props to this guy in the video below for surviving the fight with just a knife!
