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10 of the Most Memorable ‘Resident Evil’ Villains [Resident Evil at 25]

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The old saying goes that a story is only as good as its villain.

And for the Resident Evil series, there’s plenty of villains to go around.

Obviously, much like the entries in the series, some villains are more memorable than others for one reason or another, but they’ve all contributed in some way to making the franchise what it is today. So, seeing as we’re hyped up on Resident Evil for its big 2-5, it’s only fair that we take a look at those principal antagonists that made our nights and days so scary.


Ramon Salazar

While Osmund Saddler was the brains behind kidnapping the President’s daughter in Resident Evil 4 as part of a grand scheme of eventually controlling the US government, you have to admit that the diminutive Ramon Salazar is more fun. Creepy appearance aside, Salazar trades a few witty barbs with Leon, as well as providing fans one of those villains that you’d love to see go in the worst way. Sadly, it doesn’t quite work out that way, despite his final form being as over-the-top as you’d expect. Small-time, indeed.


Albert Wesker

Come on, you knew he’d be on here. Wesker is as close to being the ultimate antagonist as you can get. Slimy and terrifying, manipulative and power-hungry, all the while having method to his madness. Like all good villains, he’s had his fingers in everything, turning friends against one another, and rubbing out those who stand in his way of ultimate power. And like all good villains, he just can’t seem to stay dead. Despite what appeared to be his ultimate demise at the end of Resident Evil 5, you know that it’s a sure bet that we’ll be seeing Wesker again at some point in future installments.


Alfred/Alexia Ashford

Resident Evil Code: Veronica holds a special place for many fans with its distinctly European gothic inspirations, as well as giving fans a unique “family feud” with the Ashford twins and Redfield siblings. The cloned offspring of Veronica Ashford are pretty dysfunctional, what with Alexia having dreams of godhood thanks to her manipulated genes (and the t-Veronica virus), and Alfred being utterly insane as governor of Rockfort Island. Of course, Alfred’s situation probably wasn’t helped when years earlier, he put his sister in cryostasis in order for her to properly “mature” into her ultimate form.


William Birkin

Unlike his counterparts, it’s difficult to determine if the remake’s version of William is superior to the original. Both are pretty crappy dads who end up mutating into progressively horrific creatures. The original version did give us a nod to Alien with the chestburster moment with Ben Bertolucci. And once again, nothing beats having to face off against a monster in the final encounter as time ticks away for your escape.


Nemesis

Rivaling Wesker as one of the most popular Resident Evil characters, one could argue that the RE3 remake of Nemesis isn’t as impressive as in the original game. In the original game, Nemesis was more aggressive in his stalking of Jill, showing up almost constantly. His remake version doesn’t show up as much, but you could chalk that up to the “less is more” approach. But really, comparing the original to the remake is just splitting hairs. Nemesis, with his iconic “STAAARS…”, sheer determination (obsession?) and imposing presence (not to mention his grotesque appearance) make him a feared (and tough-as-nails) character that you would not want to mess with, rocket launcher or not.


Mr. X

Honestly, the Resident Evil 2 remake did wonders for Mr. X. The original game had him just lumbering after you. Whereas in the remake, he very much has purpose and determination in his step. Not to mention that he also knows how to use doors In the 2019 update. He also doesn’t go down as easily in the RE2 remake, whereas before you could throw everything you had at him, and eventually he’d succumb. Not in the remake! On top of it all, the remake’s version of Mr. X has the unfortunate ability to show up at the most inopportune times, adding more tension to an already scary situation.


Jack Baker

In much the same way Resident Evil 4 revived the series, Resident Evil VII did it again twelve years later. And part of that success was due to the Baker family. Comparisons of The Texas Chainsaw Massacre’s Sawyer family aside, Jack Baker is a standout terror. In addition to his superhuman strength and regenerative capabilities, it’s his flat-out psychopathy that gets you. That, and the fact that he’s complemented by the creepy Baker house that only seems to enhance his scariness. We don’t see a whole lot of him in the game, but it’s probably better that way, as his first impression definitely leaves an impact on the player.


Tyrant

Sure, the original final boss has since been surpassed by other more impressive monsters, but in 1996, this was it. There’s just something about a giant monster walking towards you that seemingly can’t be downed, no matter how much lead you introduce. Plus, if you think about it, if it wasn’t for Tyrant, you wouldn’t have its successors like Nemesis or Mr. X. And in the end, as noted before, there’s always something special about facing off against a hulking monster where you’re forced to hang tough until backup arrives.


Ada Wong

What!? Ada Wong is a villain?? Well, when you think about it, she definitely typifies being an antihero with that constant air of ambiguity around her. She still helps out Leon on more than occasion. That is, until she turns around and screws him over on those same occasions. Even then, she still sees to it that she helps Leon down the road as a way to make up for her “slight”. Ada’s backstory has never been truly explored, which only adds more mystique to her, and only strengthens her appeal.


Ozwell Spencer

One of the heads of the Umbrella Corporation, his name adorns the mansion that started this whole journey. His ruthlessness in eliminating those who stood in his way of controlling the Umbrella Corporation rivaled his god complex of remaking the world in his image. Of course, the entire irony of it all is Ozwell meeting his ultimate fate at the hands of Wesker, who was one of the first steps in Spencer’s pursuit of creating a utopia.

Editorials

Five Serial Killer Horror Movies to Watch Before ‘Longlegs’

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Pictured: 'Fallen'

Here’s what we know about Longlegs so far. It’s coming in July of 2024, it’s directed by Osgood Perkins (The Blackcoat’s Daughter), and it features Maika Monroe (It Follows) as an FBI agent who discovers a personal connection between her and a serial killer who has ties to the occult. We know that the serial killer is going to be played by none other than Nicolas Cage and that the marketing has been nothing short of cryptic excellence up to this point.

At the very least, we can assume NEON’s upcoming film is going to be a dark, horror-fueled hunt for a serial killer. With that in mind, let’s take a look at five disturbing serial killers-versus-law-enforcement stories to get us even more jacked up for Longlegs.


MEMORIES OF MURDER (2003)

This South Korean film directed by Oscar-winning director Bong Joon-ho (Parasite) is a wild ride. The film features a handful of cops who seem like total goofs investigating a serial killer who brutally murders women who are out and wearing red on rainy evenings. The cops are tired, unorganized, and border on stoner comedy levels of idiocy. The movie at first seems to have a strange level of forgiveness for these characters as they try to pin the murders on a mentally handicapped person at one point, beating him and trying to coerce him into a confession for crimes he didn’t commit. A serious cop from the big city comes down to help with the case and is able to instill order.

But still, the killer evades and provokes not only the police but an entire country as everyone becomes more unstable and paranoid with each grizzly murder and sex crime.

I’ve never seen a film with a stranger tone than Memories of Murder. A movie that deals with such serious issues but has such fallible, seemingly nonserious people at its core. As the film rolls on and more women are murdered, you realize that a lot of these faults come from men who are hopeless and desperate to catch a killer in a country that – much like in another great serial killer story, Citizen X – is doing more harm to their plight than good.

Major spoiler warning: What makes Memories of Murder somehow more haunting is that it’s loosely based on a true story. It is a story where the real-life killer hadn’t been caught at the time of the film’s release. It ends with our main character Detective Park (Song Kang-ho), now a salesman, looking hopelessly at the audience (or judgingly) as the credits roll. Over sixteen years later the killer, Lee Choon Jae, was found using DNA evidence. He was already serving a life sentence for another murder. Choon Jae even admitted to watching the film during his court case saying, “I just watched it as a movie, I had no feeling or emotion towards the movie.”

In the end, Memories of Murder is a must-see for fans of the subgenre. The film juggles an almost slapstick tone with that of a dark murder mystery and yet, in the end, works like a charm.


CURE (1997)

Longlegs serial killer Cure

If you watched 2023’s Hypnotic and thought to yourself, “A killer who hypnotizes his victims to get them to do his bidding is a pretty cool idea. I only wish it were a better movie!” Boy, do I have great news for you.

In Cure (spoilers ahead), a detective (Koji Yakusho) and forensic psychologist (Tsuyoshi Ujiki) team up to find a serial killer who’s brutally marking their victims by cutting a large “X” into their throats and chests. Not just a little “X” mind you but a big, gross, flappy one.

At each crime scene, the murderer is there and is coherent and willing to cooperate. They can remember committing the crimes but can’t remember why. Each of these murders is creepy on a cellular level because we watch the killers act out these crimes with zero emotion. They feel different than your average movie murder. Colder….meaner.

What’s going on here is that a man named Mamiya (Masato Hagiwara) is walking around and somehow manipulating people’s minds using the flame of a lighter and a strange conversational cadence to hypnotize them and convince them to murder. The detectives eventually catch him but are unable to understand the scope of what’s happening before it’s too late.

If you thought dealing with a psychopathic murderer was hard, imagine dealing with one who could convince you to go home and murder your wife. Not only is Cure amazingly filmed and edited but it has more horror elements than your average serial killer film.


MANHUNTER (1986)

Longlegs serial killer manhunter

In the first-ever Hannibal Lecter story brought in front of the cameras, Detective Will Graham (William Petersen) finds his serial killers by stepping into their headspace. This is how he caught Hannibal Lecter (played here by Brian Cox), but not without paying a price. Graham became so obsessed with his cases that he ended up having a mental breakdown.

In Manhunter, Graham not only has to deal with Lecter playing psychological games with him from behind bars but a new serial killer in Francis Dolarhyde (in a legendary performance by Tom Noonan). One who likes to wear pantyhose on his head and murder entire families so that he can feel “seen” and “accepted” in their dead eyes. At one point Lecter even finds a way to gift Graham’s home address to the new killer via personal ads in a newspaper.

Michael Mann (Heat, Thief) directed a film that was far too stylish for its time but that fans and critics both would have loved today in the same way we appreciate movies like Nightcrawler or Drive. From the soundtrack to the visuals to the in-depth psychoanalysis of an insanely disturbed protagonist and the man trying to catch him. We watch Graham completely lose his shit and unravel as he takes us through the psyche of our killer. Which is as fascinating as it is fucked.

Manhunter is a classic case of a serial killer-versus-detective story where each side of the coin is tarnished in their own way when it’s all said and done. As Detective Park put it in Memories of Murder, “What kind of detective sleeps at night?”


INSOMNIA (2002)

Insomnia Nolan

Maybe it’s because of the foggy atmosphere. Maybe it’s because it’s the only film in Christopher Nolan’s filmography he didn’t write as well as direct. But for some reason, Insomnia always feels forgotten about whenever we give Nolan his flowers for whatever his latest cinematic achievement is.

Whatever the case, I know it’s no fault of the quality of the film, because Insomnia is a certified serial killer classic that adds several unique layers to the detective/killer dynamic. One way to create an extreme sense of unease with a movie villain is to cast someone you’d never expect in the role, which is exactly what Nolan did by casting the hilarious and sweet Robin Williams as a manipulative child murderer. He capped that off by casting Al Pacino as the embattled detective hunting him down.

This dynamic was fascinating as Williams was creepy and clever in the role. He was subdued in a way that was never boring but believable. On the other side of it, Al Pacino felt as if he’d walked straight off the set of 1995’s Heat and onto this one. A broken and imperfect man trying to stop a far worse one.

Aside from the stellar acting, Insomnia stands out because of its unique setting and plot. Both working against the detective. The investigation is taking place in a part of Alaska where the sun never goes down. This creates a beautiful, nightmare atmosphere where by the end of it, Pacino’s character is like a Freddy Krueger victim in the leadup to their eventual, exhausted death as he runs around town trying to catch a serial killer while dealing with the debilitating effects of insomnia. Meanwhile, he’s under an internal affairs investigation for planting evidence to catch another child killer and accidentally shoots his partner who he just found out is about to testify against him. The kicker here is that the killer knows what happened that fateful day and is using it to blackmail Pacino’s character into letting him get away with his own crimes.

If this is the kind of “what would you do?” intrigue we get with the story from Longlegs? We’ll be in for a treat. Hoo-ah.


FALLEN (1998)

Longlegs serial killer fallen

Fallen may not be nearly as obscure as Memories of Murder or Cure. Hell, it boasts an all-star cast of Denzel Washington, John Goodman, Donald Sutherland, James Gandolfini, and Elias Koteas. But when you bring it up around anyone who has seen it, their ears perk up, and the word “underrated” usually follows. And when it comes to the occult tie-ins that Longlegs will allegedly have? Fallen may be the most appropriate film on this entire list.

In the movie, Detective Hobbs (Washington) catches vicious serial killer Edgar Reese (Koteas) who seems to place some sort of curse on him during Hobbs’ victory lap. After Reese is put to death via electric chair, dead bodies start popping up all over town with his M.O., eventually pointing towards Hobbs as the culprit. After all, Reese is dead. As Hobbs investigates he realizes that a fallen angel named Azazel is possessing human body after human body and using them to commit occult murders. It has its eyes fixated on him, his co-workers, and family members; wrecking their lives or flat-out murdering them one by one until the whole world is damned.

Mixing a demonic entity into a detective/serial killer story is fascinating because it puts our detective in the unsettling position of being the one who is hunted. How the hell do you stop a demon who can inhabit anyone they want with a mere touch?!

Fallen is a great mix of detective story and supernatural horror tale. Not only are we treated to Denzel Washington as the lead in a grim noir (complete with narration) as he uncovers this occult storyline, but we’re left with a pretty great “what would you do?” situation in a movie that isn’t afraid to take the story to some dark places. Especially when it comes to the way the film ends. It’s a great horror thriller in the same vein as Frailty but with a little more detective work mixed in.


Look for Longlegs in theaters on July 12, 2024.

Longlegs serial killer

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