In a recent blog post on his site, Edmund McMillen revealed that the music in the upcoming rogue-like game The Binding Of Isaac: Rebirth will actually change based upon the items that the character picks up.
McMillen writes, “…the cool thing about the music in [R]ebirth is there will be a few items that warm how things sound… and a lot of the tracks sound amazing when they are slowed down or sped up”
This was a response to a writer telling McMillen that a new track, “Duress”, sounded extremely sinister when played backwards. You can listen to that track below.